Variance-Component-Based Meta-Analysis of Gene-Environment Interactions for Rare Variants
نویسندگان
چکیده
منابع مشابه
Meta-analysis of gene-level associations for rare variants based on single-variant statistics.
Meta-analysis of genome-wide association studies (GWASs) has led to the discoveries of many common variants associated with complex human diseases. There is a growing recognition that identifying "causal" rare variants also requires large-scale meta-analysis. The fact that association tests with rare variants are performed at the gene level rather than at the variant level poses unprecedented c...
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ژورنال
عنوان ژورنال: G3 Genes|Genomes|Genetics
سال: 2021
ISSN: 2160-1836
DOI: 10.1093/g3journal/jkab203